Monoclonal antibody specific to a novel epitope of

专利名称：Monoclonal antibody specific to a novel

epitope of the LFA-1 antigen of human Tlymphocytes

发明人：Stuart F. Schlossman,Chikao Morimoto申请号：US07/116514申请日：19871102公开号：US05002869A公开日：19910326

摘要：A monoclonal antibody which binds preferentially to a subset of the human CD8lymphocyte population whereby to positively and precisely distinguish between cytotoxiceffector and supressor effector cells in the CD8 cell population. The monoclonalantibody recognizes a novel epitope of LFA-1 antigen by means of which it can bind CD8cells which express the eptope on a surface antigen thereof. The CD8 subset cellpopulation to which this anitbody binds preferentially is the CD8 cytotoxic effectorpopulation. This selectivity of the monoclonal antibody enables cell sorting, diagnosticand positive therapeutic applications thereof to be utilized.

申请人：DANA-FARBER CANCER INSTITUTE

代理人：Myron C. Cass

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