Novel protein and monoclonal antibody specific the

专利名称：Novel protein and monoclonal antibody

specific thereto

发明人：Motoharu Seiki,Hiroshi Sato,Akira Shinagawa申请号：US09734002申请日：20001212

公开号：US20010016333A1公开日：20010823

摘要：A novel protein which is useful as diagnostic means for the studies relating tothe diagnosis and treatment of cancer (detection of cancer cells, estimation of themalignity, etc.) and in other medicinal and physiological purposes; a gene encoding thesame; and an antibody, in particular, a monoclonal antibody specific to the protein. MT-MMP-3, which is a pro MMP-2 activator having the ability to activate pro MMP-2 which isunder expression specifically on the surface layer of a human cancer cell and falling withinthe category of MMP but being different from MT-MMP-1; a DNA containing the basesequence encoding the same; host cells transformed by the DNA; a process forproducing a matrix metalloproteinase protein by using the host cells; a monoclonalantibody binding specifically to the matrix metalloproteinase protein; and use of theprotein and antibody.

申请人：SEIKI MOTOHARU,SATO HIROSHI,SHINAGAWA AKIRA

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